Hairy cell leukemia: a case report.

Hairy cell leukemia (HCL) is a relatively rare, chronic B-cell lymphoproliferative disorder characterized by splenomegaly, pancytopenia and bone marrow infiltration by hairy cells with circumferential prominent hairy cytoplasmic projections. Splenomegaly with few atypical lymphoid cells in peripheral blood lead to the examination of bone marrow for morphological findings characteristic of hairy cell leukemia (HCL) with an increased reticulin framework. Diagnosis is confirmed when flow cytometry is positive for hairy cell markers including CD11c, CD103 and FMC-7. BRAF mutation is also positive in present case which re-confirms the diagnosis.